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Extensive laboratory testing has shown that it's not the magnetic field strength, but the field gradient (steepness of the slope of the magnetic field) that is the determining factor in alleviating pain. This unique steep field gradient generated by the Quadrapolar array is what blocks the pain signal. This is why the QuadraBloc™ Science is so effective when placed over the irritated nerve. Over a decade of cell research was done at Vanderbilt University Medical Center in Nashville Tennessee and clinical data was collected at various Medical Centers and Universities around the world. |
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BLOCKADE OF SENSORY NEURON ACTION POTENTIALS BY A STATIC MAGNETIC FIELD in the 10 mT RANGE
M.J. McLean, R.R. Holcomb, A.W. Wamil, Joel D.
Pickett and A.V. Cavopol INTRODUCTION Variable effects of static magnetic fields on electrophysiological properties of neural tissue have been reported. A 660 mT field reduced spontaneous firing of action potentials of cockroach subesophageal ganglion neurons (Sittler, 1966). The amplitude of the compound action potential of frog sciatic nerve increased in a perpendicular, but not a parallel, field of 100-712 mT (Edelman et al., 1979). Also, amplitude of the compound action potential of rat tail nerve increased in a field >0.5 T for longer than 30 s (Hong et al., 1986). In a study employing intracellular microelectrode recording techniques, input resistance of inactive identified snail neurons was reduced significantly by static fields of 23-200 mT field; input resistance increased in spontaneously firing neurons exposed to similar fields (Balaban et al., 1990). On the other hand, action potentials and voltage-clamped transmembrane currents of lobster nerve were unaffected by a perpendicular or parallel 1.2 T field (Schwartz, 1979). Technical aspects, such as warming of preparations by heat radiating from electromagnets, could have resulted in falsely positive results, as pointed out by Gaffey and Tenforde (1983). Calcium flux has been altered at the neuromuscular junction of the mouse by a 120 mT field (Rosen, 1992). In addition, the decrease in amplitude and variability of cat visual evoked responses in a 120 mT field began after a latency of about a minute and persisted for several minutes after the electromagnet was turned off (Rosen and Lubowsky, 1987). Consistent with these results showing an inhibitory effect of static fields on excitable tissues, we have shown reduction of action potential firing by cultured adult mouse dorsal root ganglion neurons positioned near the center of 10-30 mT static fields produced by arrays of four permanent center-charged magnets of alternating polarity (abbreviated here MAG-4A; McLean et al., 1991). This array had previously been shown to have analgesic effects in patients (Holcomb et al., 1991a). Using cultured sensory neurons, we have determined several features of the biological effect of the magnetic field (McLean et al., 1991).
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